CJ-VOLUME 06 ISSUE 01 JANUARY 2016


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Volume 6 Issue 1, January 2016

Chemistry Journal

ISSN

2049-954X

Publication Frequency

6 Issues per year

Pages

1-31

Publication History


Original Articles

Vanadium-Catalyzed Esterification of Carboxylates: Synthesis, X-Ray Crystal Structure and Biological Studies

Khurram Shahzad Munawar, Saqib Ali, Nasir Khalid, Muhammad Nawaz Tahir and Syed Mustansar Abbas

Pages 1-9


Rapid Assessment of Cell Viability Based on Glucose Consumption Measurement using a Diabetes Blood Glucometer

Hweiyan Tsai, Wei-Jen Ting, Peilin Wu, Chih-Chung Hsieh, Numan Tsai and Xiao-Fan Huang

Pages 10-14

Electrochemical Relaxation Study on the Electrosynthesised Methylt-hiophene and Bromothiophene as Conducting Copolymer

A.A. El Maghraby and A.M. Kotb

Pages 15-21

Synthesis, Spectroscopic and Antimicrobial Properties of Some Metal (II) Complexes of Mixed Ligands -Nicotinic and N,N’-Dimethyldithio-carbamic Acids

Aderoju A. Osowole, Sherifah M. Wakil, Esther Q. Okediran and Olaoluwa K. Alao

Pages 22-26

Studies on Some Metal(II) Complexes of Mixed Ligands- Benzoic and N, N’-Dimethyldithiocarbamic Acids

Aderoju A. Osowole, Sherifah M. Wakil, Esther Q. Okediran and Olaoluwa K. Alao

Pages 27-31



Title

Vanadium-Catalyzed Esterification of Carboxylates: Synth-esis, X-Ray Crystal Structure and Biological Studies

Abstract

The potentials of vanadium (III) chloride as catalyst were checked for the esterification of substituted carboxylic acids with methanol. The synthesised precursors and methyl esters formed were charact-erised by various analytical techniques such as FT-IR, 1H-NMR, 13C-NMR and single crystal analysis. The antimicrobial activities of the carboxylates and their methyl est-ers were found good against various strains of bacteria (Escherichia coli, Bacillus subtilis, Staph-ylococcus aureus and Pasteurella multocida) and fungi (Alternaria alternata, Ganoderma lucidum and Penicillium notatum). All these esters were tested for their activity against the alkaline phosphatase (ALP) and Methyl 4-oxo-4-(2,4,6-trichlorophenylamino)but-2-enoa-te (compound 1) was found to be potent inhibitor while Methyl 4-(3, 4-dichlorophenylamino)-4-oxobut-2-enoate (compound 2) showed intercalative mode of binding with DNA.

Keywords

Vanadium, Coordination Modes, Vibrational Spectroscopy, Antimicrobial Activities, Bacteria, Fungi

Title

Rapid Assessment of Cell Viability Based on Glucose Consu-mption Measurement using a Diabetes Blood Glucometer

Abstract

This study explored to assess cell viability using a general diabetes blood glucose meter. Cell viabilities were assessed on the basis of gl-ucose consumption and compared with those measured using a MTT assay. The statistical analysis showed the consistency of the re-sults of two methods. Cell viability assessments on the basis of the glucose consumption in the culture medium are suitable for applica-tions of various cancer cell lines and epithelial cell lines. The blood glucometer meets the needs of instant viability assessment during cell culture with calibration-free, and maintenance-free. This device detected the cell viability on the basis of the glucose consumption in the culture medium. It is economical and the cultured cells can be used for further mechanism study of drug effects.

Keywords

Glucose Analysis, Cell Viability, Blood Glucometer

Title

Electrochemical Relaxation Study on the Electrosynthesis-ed Methylthiophene and Bromothiophene as Conducting Copolymer

Abstract

This study aims to determine the optimum conditions that enable to obtain a stable and high sensitive copolymer films have lower relax-ation time. The electrosynthesis of both the polymer and copolymer films were carried out from 3-methylthioph-ene and 3-bromothiop-hene monomers using galvanostatic and potentiodynamic techniq-ues. The stability and electrical conductivity of the prepared films have been studied. The most stable copolymer film was obtained galvanostatically in nitrobenzene solvent and tetrabutyl ammonium hexafluorophosphate as supporting electrolyte. A comparison relax-ation study was performed for the prepared homopolymer and copolymer films using the cyclic voltammetric technique in different solvents. The effects of many factors on the relaxation time were investigated. It was found that the galvanostatic synthesized copol-ymer film has lower relaxation time and higher sensitivity than the corresponding homopolymers and also the potentiodynamic synthe-sised copolymer film. When the donor number of the solvent increa-ses the relaxation time is decreased. Tetrabutylammonium hexaflu-orophosphate as an electrolyte gives the most sensitive copolymer film, which has the lowest relaxation. As the concentration of one of the monomers increases the relaxation time decreases. The relaxati-on time is also highly affected by temperature.  

Keywords

Electropolymerisation, Relaxation Study, Conducting Copolymer, Polythiophene

Title

Synthesis, Spectroscopic and Antimicrobial Properties of Some Metal (II) Complexes of Mixed Ligands -Nicotinic and N,N’-Dimethyldithiocarbamic Acids

Abstract

Some metal(II) mixed ligand complexes of nicotinic and dimethyldi-thiocarbamic acids were synthesized (M = Mn, Fe, Co, Ni, Cu and Zn) and characterised by solubility, percentage metal analysis, con-ductivity, infrared and electronic spectra me-asurement. Electronic spectra and room temperature magnetic moments indicated that the metal complexes mostly exhibit-ed spin-cross over, that is equili-brium between high spin and low spin octahedral, while the Cu(II) and the Zn(II) complex-es were anti-ferromagnetic and diamagnet-ic respectively. The conductance and infrared spectra measuremen-ts showed that the complexes were non-electrolytes and coordinati-on was through the carbonyl oxygen and pyridine nitrogen atoms of Nicotinic acid and the two sulphur atoms of the dimethyldithiocarb-amic acid respectively. The in-vitro antimicrobial activities of the metal-free nicotinic acid, N,N’-dimethyldithiocarbamic acid and their metal complexes against E. coli, Streptococcus sp, Proteus sp, Streptococcus pyogenes, Candida sp, Salmonella sp, Bacillus spp, Staphylococcus sp and Pseudomonas spp were mostly very good. Interestingly, the sodium-N,N’-dimethyldithiocarbamate, Mn(II), Fe(II), Cu(II) and Zn(II) complexes had broad spectrum antimicrob-ial activities just like Streptomycin (7.0-33.0 mm) with inhibitory zon-es ranges of 10.0-33.0 mm, 9.0-31.0 mm, 9.0-31.0 mm, 7.0-23.0 mm, and 9.0-21.0 mm respectively, proving their potentia-ls as broad-spectrum antimicrobial agents in-vitro.

Keywords

Antimicrobial, Dimethyldithiocarbamic Acid, Nicotinic Acid, Spin Cross Over, Geometry

Title

Studies on Some Metal(II) Complexes of Mixed Ligands- Benzoic and N, N’-Dimethyldithiocarbamic Acids

Abstract

Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes of the mixed ligan-ds- N, N’-dimethyl dithiocarbamic and benzoic acids were synthesis-ed and characterised by electronic and IR spectroscopies, percent-age metal analysis, conductance, magnetic moments  and melting point measurements. Percentage metal analysis, conductance and magnetic moment data indicated that the Cu(II) and Zn(II) comple-xes were magnetically dilute and octahedral, whereas the Fe(II), Co(II) and Ni(II) comple-xes exhibited spin-crossover and antiferro-magnetism respectively. The infrared spectra indicated that coordi-nation to the metal atoms was through O2S2 chromophores of the benzoic and dithiocarbamic acids respectively. The in-vitro antimic-rob-ial activities of the metal-free benzoic and N,N’-dimethyl dithio-carbamic acids, and their metal complexes against Proteus sp, Streptococcus pyogenes, Candida sp, Salmonella sp, Bacillus sp (Fo-od strain), Staphylococcus sp, Pseudomonas sp (Clinical strain), Pseudomonas sp (Environmental strain), Bacillus sp (Environment-al strain) and E. coli showed that both acids, the Fe(II), Co(II) and Zn(II) complexes  had broad-spectrum antimicrobial activities with inhibitory zones ranges of 10.0-21.0 mm, 7.0-13.0 mm, 13.0-25.0 mm, 6.0-19.0 mm and 7.0-25.0 mm respectively, proving their pote-ntials as broad spectrum antimicrobial agents.

Keywords

Metal(II) Complexes, Mixed Ligands, Benzoic, N, N’-Dimethyldithiocarbamic Acids