RJB-VOLUME 01 ISSUE 01 NOVEMBER 2011


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Research Journal of Biology (RJB)               ISSN 2049-1727
Volume 01 No.01 November 2011 (Pages 1-20)



Title

Linkage Study of Primary Microcephaly in Pakistani Kindred 

Author(s)

Saba Irshad, Sana Anwar and Blessy Shehzad


Abstract

Microcephaly is heterogeneous, autosomal recessive trait with reduced head circumference of at least 4 SD below age and sex means due to reduction in neuron production. The brain of microcephalic patient is architecturally normal but severe to mild mental retardation. It is rare disease affecting 2-2.5% of total population specifically in Asia and Arab where the incidence of cousin marriages is relatively high. From seven known currently mapped loci ASPM is found to be the frequent causative agent. In the current investigations exclusion mapping of a microcephalic family was done. DNA from all blood samples was extracted using standard procedure and after gene specific PCR amplifications, 8% non-denaturing PAGE was done. Linkage was observed at MCPH5 locus where ASPM is a candidate gene on chromosome 1q31. The results of DNA sequencing showed G to A transition and Leucine (CTG) to Leucine (CTA) was noted. There are six triplet codons which differ by single nucleotide encoding for Leucine. Hence, no overall change in the effect of protein expression was observed due to the degeneracy of codons. Therefore, the sequencing of the entire ASPM gene with intervening sequences was suggested in order to find the actual cause of microcephaly.

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Title

Study of Maternal Age, Family History of Mental Retardation, Consanguinity in Mental Retardation (Various Risk Factors in Mental Retardation)

Author(s)

Minakshi Vashist and  Ritu Yadav


Abstract

Mental retardation is significantly sub average intellectual functioning present from birth or early infancy, causing limitations in the ability to conduct normal activities of daily living. Level of mental retardation, maternal age, family history of mental retardation and consanguinity associated disorder was recorded from data given by parents or center of rehabilitation. Forty seven percent mentally retarded patients were born to the mother’s of age 21-25 years. There were 4% mentally retarded patients in 41-45 age groups. Order of birth varied from 1-3 in family history of mental retardation. Consanguinity was recorded in 16 cases of mental retardation. The information on possible risk factors can be used for genetic counseling and pregnancy supervision. Proper monitoring of risk factors could prevent our human health system from a serious life long disability and burden of the society could be reduced.

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Title

Impact of Ganesh Idol Immersion Activities on The Water Quality of Tapi River, Surat (Gujarat) India

Author(s)

N. C. Ujjania , Azhar A. Multani


Abstract

In this paper the impact of Ganesh idol immersion on water quality of Tapi River is discussed, for this purpose Ashwanikumar immersion point (Ovara) was selected as sampling station because large number of Ganesh idols immersed on this Ghat of Tapi River. Water samples were collected at morning hours during pre immersion, during immersion and post immersion periods of Ganesh idols. The changes in physico-chemical properties of Tapi River were observed except temperature, pH and DO with minor changes while CO2, BOD, COD, total alkalinity, total hardness, total calcium, and oil & grease were observed with major changes during immersion period. On the basis of these changes it is concluded that level of water pollution increases in Tapi River due to these religious activities and causes adverse effect on the aquatic ecosystem. No one can stop these religious activities but awareness among the people and society can reduce the pollution.

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Title

Folklore Claims of Some Medicinal Plants Used By Tribal Community of Chhattisgarh, India

Author(s)

Amia Ekka


Abstract

The sea-horse shaped Chhattisgarh state come into existence on 1st November 2000 by the Bill “Madhya Pradesh Reorganisation Act. 2000” passed in the parliament. Until then it was a part of Madhya Pradesh state.  The significant tribes of the state are: Gond, Korwa, Manjhi, Oraon, Munda, Baiga, Nagesia, Kol, Agarias etc. The life style of tribal people depends upon the land. Agriculture, hunting, fishing, collection of forest products, bamboo work or labour of any kind are their livelihood. The rich tribal areas are Raigarh, Jashpur, Surguja & Baster districts; tribes are still unaware of the scientific and cultural progress of the society and still are being exploited by the people of the modern society. This paper reports the results of an ethnobotanical study conducted in Chhattisgarh i.e. in Baster, Jagdalpur, Surguja, Korba, Raigarh and Jashpur districts. Folk uses are described for twenty five species, of which five are for food, seventeen for medicines, and four for miscellaneous uses, such as oil, dye, fodder, etc. These species are used among the Oraon, Gonds, Korwas, Majhwars, Bharias, Halba and Chamars of the region. About three uses reported here seem to be les known (Jain,  1991) in India, or not recorded for the region. Some magico-religious beliefs about plants prevalent. in the area have been mentioned for record. 

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