CJ-VOLUME 02 ISSUE 01 JANUARY 2012


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Volume 2 Issue 1, January 2012

Chemistry Journal

ISSN

2049-954X

Publication Frequency

6 Issues per year

Pages 

1-37

Publication History


Original Articles

Substituent Effect in the γ–Position of Acetylacetonate on the Solvatochromic Property of bis(ac-etylacetonato) Copper (II) Complexes

Hamid Golchoubian and Fariba Khoshsiar

Pages 1-8

Hydrogen Peroxide Radical Scavenging and Total Antioxidant Activity of Hawthorn

Serhat Keser, Sait Celik, Semra Turkoglu, Ökkes Yilmaz and Ismail Turkoglu

Pages 9-12

Synthesis and Structural Characterization of Novel Monoesters of Succinic Anhydride with Aryl Alcohols

Muhammad Iqbal, Imam Bakhsh Baloch and Musa Kaleem Baloch

Pages 13-20

Synthesis, Characterization and Antibacterial Evaluation of Some Arylideneaminotetrahydroben-zothiazoles

M.M.H. Bhuiyan and A.S.M. Mustafa Kamal

Pages 21-25

Antiradical Activity and Spectroscopic Studies of [3,5-Diamino-4-(4-Nitro-Pheny-lazo)-1H-Pyra-zole]  and Complexes

Zuhal Karagoz,  Serhat Keser, Naki Çolak, Memet ┼×ekerci and S. Seyma Acar

Pages 26-30

Microwave Assisted Knoevenagel Condensation: Synthesis and Antimicrobial Activities of Some  Arylidene-Malononitriles 

M.M.H. Bhuiyan, M.I. Hossain, M. Ashraful Alam and M.M. Mahmud

Pages 31-37

Title

Substituent Effect in the γ–Position of Acetylacetonate on the Solvatochromic Prop-erty of bis(acetylacetonato) Copper (II) Complexes

Abstract

Solvatochromic properties of a series of bis (3–substituted derivatives of acetylaceto-ne) copper (II), [Cu(X-acac)2], (X = Cl, H. CH3) complexes were studied. All the comple-xes demonstrated negative solvatochromism. Among the complexes the Cu(Cl-acac)2, demonstrated the most solvatochromism (= 4030 cm-1). Their solvatochromism were also investigated with different solvent parameters models such as Dimroth and Reichardt’s ET(30), Kosower's Z, Kamlet and Taft’s α, β, π*, Gutmann’s donor DN and acceptor number AN using stepwise multiple linear regression (SMLR) method. The results obtained by SPSS/PC software suggested that the DN parameter of the solvent has the dominate contribution to the shift of the d-d absorption band of the complexes to lower wave numbers with increasing its values. The statistical evaluations of the data (R, S. E., F-test, Q2 and PRESS/SSY) also confirm the suggested parameter. All complexes show good cross-validation values (Q2 > 0.70; Q= 0.72 - 0. 92). This phenomenon is interpreted based on the coordination of the solvent molecules along the axial positions of the complexes.

Keywords

Solvatochromis, Multiple Linear Regression, Visible Spectroscopy, Copper (II) Complex, Acetylacetonate


Title

Hydrogen Peroxide Radical Scavenging and Total Antioxidant Activity of Hawthorn

Abstract

The aim of this research is to determine H2O2 radical scavenging and total antioxidant activity of Crataegus monogyna (hawthorn) water and ethanol extracts of leaves, flowers and fruits. Hawthorn leaves, flowers, and berries are used in traditional medicine in the treatment of chronic heart failure, high blood pressure, arrhythmia, and various digestive ailments, as well as geriatric and antiarteriosclerosis remedies. In this study, ethanol and water extracts were prepared from powdered C. monogyna flowers, leaves and fruits. Antioxidant activities were measured by ferric thiocyanate method, H2O2 radical scavenging assays with UV-Vis spectrophotometer. In conclusion, C. monogyna flowers, leaves and fruits had H2O2 radical scavenging, total antioxidant activ-ity, and these antioxidant activities were compared with BHA and α-tocopherol as reference antioxidants. The results of this study show that the water and ethanol extracts ofC. monogyna can be used as easily accessible source of natural antioxidants and as a possible food supplement or in pharmaceutical industry.

Keywords

Crataegus monogyna, Hawthorn, Total Antioxidant, H2O2


Title

Synthesis and Structural Characterization of Novel Monoesters of Succinic Anhydr-ide with Aryl Alcohols

Abstract

Industrial, pharmaceutical and daily life applications of esters are countless; among these, the esters of succinic anhydride are particularly important and have numerous applications. Therefore, they have attained much attention in the last decades and a number of techniques have been proposed to synthesize these compounds. However, the available techniques for the synthesis of these important compounds have some demerits and need to be addressed properly. In most of the cases, costly and dangero-us chemicals are used as a reactant or catalyst although such chemicals enhance the hazard chances and environment issues but provide low yield. Therefore, a new techni-que has been proposed to open the ring of succinic anhydride using p-toluene sulphonic acid as a catalyst to get monoesters (1-29) of aryl alcohols. The aryl alcohols used were having electron donating or electron withdrawing groups. The prepared monoesters were separated using chromatographic techniques and their structure was confirmed by IR, UV, 1D, 2D, (1H and 13C) NMR spectra and mass measurements.  

Keywords

Succinic Anhydride, Aryl Alcohols, Monoesters of Succinic Acid, 1D NMR, 2D NMR of Monoesters


Title

Synthesis, Characterization and Antibacterial Evaluation of Some Arylideneaminot-etra-hydrobenzothiazoles

Abstract

The starting material, 2-amino-4,5,6,7-tetrahydrobenzo[d]thiazole (1), was prepared from cyclohexanone and thiourea in  the presence of iodine under heating on a water bath with occasional stirring. Reaction of 2-amino-4,5,6,7-tetrahydrobenzo -[d]thiazole (1) with various aromatic aldehydes afforded 2-arylideneamino-4,5,6,7-tetrahydroben-zo[d]thiazole derivatives (2-8) in excellent yields. The structures of the synthesized thiazole derivatives have been established on the basis of their IR, NMR spectral data and elemental analyses. The obtained compounds were screened for their antibacterial activities against three Gram-positive pathogenic organisms: Bacillus cereus (BTCC 19), Bacillus subtilis (BTCC 17), Staphylococcus aureus (ATCC 6538) and against six Gram-negative pathogenic organisms: Shigella dysenteriae (AE 14396), Salmonella typhi(AE 14612), Pseudomonous aeruginosa, Vibrio choleraeEscherichia coli (ATCC 25922)and Salmonella paratyphi (Table 1). The disc diffusion method was used for antibacterial activities. Some of them were found to possess significant activity, when compared to standard drug. 

Keywords

Aminothiazole, Arylideneaminothizole, Antibacterial Activity


Title

Antiradical Activity and Spectroscopic Studies of [3, 5-Diamino-4-(4-Nitro-Phenylazo )-1H-Pyrazole]  and Complexes

Abstract

Azo compounds are known to be involved in a number of biological reactions such as inhibition of DNA, RNA, and protein synthesis, carcinogenesis, and nitrogen fixation. In this study, 4-[3,5-Diamino-4H-pyrazol-4-yl)diazenly]benzoic acid (L) has been synthesized starting from 4-Phenyl-hydrazonomalononitrile-carboxylic acid, the metal complexes of the ligand 4-[3,5-Diamino-4H-pyrazol-4-yl)diazenly]benzoic acid (L) were prepared with acetate Co(II), Ni(II) and Cu(II) in DMF as solvent. The ligand (L) and its metal complexes have been characterized by elemental analyses, IR, 1H-NMR spectra, magnetic susceptibility, UV-Visible and thermogravimetry-differential thermal analysis (TGA-DTA). Antiradical activity was measured by 1,1-diphenyl-2-picryl-hydrazil (DPPH) radical scavenging assay. The ligand and its compounds were not showed high antiradi-cal scavenging activity when compared to standard antioxidant tocopherol. The sugge-sted structures for the L complex of Co(II) is octahedral, for the Ni(II) complex is tetra-hedral, and for the Cu(II) complex square-planar.

Keywords

Amine Compounds, Antiradical Activity, Metal Complexes, Spectroscopic Studies

Title
Microwave Assisted Knoevenagel Condensation: Synthesis and Antimicrobial Activi-ties of Some  Arylidene-malononitriles 
Abstract

Eleven arylidene-malononitriles, viz. 2-(1-naphthylidene)-malononitrile (1)2-(4-N,N-dimethylaminobenzylidene)-malononitrile (2), 2-(4-hydroxy-3-methoxybenzy-lidene)-malononitrile (3), 2-(3-methoxybenzylidene)-malononitrile (4), 2-(2-met-hylbenzylide-ne)-malononitrile(5), 2-(4-hydroxybenzylidene)-malononitrile (6), 2-(3-methylbenzylid-ene)-malononitrile (7), 2-(2,4-dimethoxybenzylidene)-malono-nitrile (8), 2-(3-nitrobe-nzylidene)-malononitrile (9), 2-(9-anthracenylidene)-malo-nonitrile (10) and 2-[3-(4-dimethylaminophenyl)-allylidene]-malononitrile (11) were prepared by Knoevenagel condensation reaction of malononitrile with corresponding aromatic aldehydes in prese-nce of ammonium acetate (NH4OAc), using microwave irradiation under solvent free condition. The reaction is clean with shorter reaction time, mild reaction condition, eco-friendly, excellent yields as compared to conventional methods and reduces the use of volatile organic compounds (VOCs). Variety of functional groups such as nitro, chloro, amino and ether survived under the reaction conditions. The structures of the arylidene-malononitriles have been established on the basis of their IR, NMR spectral data and elemental analyses. These compounds were screened for their antibacterial activities against five pathogenic organisms: Bacillus cereus (BTCC 19),Staphylococcus aureus (ATCC 6538), Vibrio choloriaeShigella dysenteriae (AE 14396) and Salmonella typhi (AE 14612) (Table 1) and antifungal activities against two organis-ms: Aspargilllus flavus and Saccharomyces cerevisiae (Table 2) using disc diffusion method and poisoned-food technique respectively. Some of them were found to posse-ss significant activity, when compared to standard drugs. 

Keywords Arylidene-malononitriles, Microwave Irradiation, Antimicrobial Activity