JP-VOLUME 01 ISSUE 01 JANUARY 2013


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Volume 1 Issue 1, January 2013

Journal of Pharmaceuticals

ISSN

2052-0743

Publication Frequency

6 Issues per year

Pages

1-11

Publication History


Original Articles

Effect of Certain Pharmaceutical Polymers on Lomefloxacin Activity against Helicobacter pylori

Amir Ibrahim Mohamed, Nermeen Samir, Eman Ahmed El-Seidi, Rania Mohammed Hafez Hathout, Gehanne Abdel Samie Awad

Pages 1-11


Title

Effect of Certain Pharmaceutical Polymers on Lomefloxacin Activity against Helicobacter pylori

Abstract

Helicobacter pylori infection is the main cause of gastritis and duodenal ulcer disease, and is associated with gastric cancer. The most important reason for incomplete H. pylori eradication by antimicrobial therapy is that the residence time of antimicrobial agents in the stomach is so short that effective antimicrobial concentrations cannot be achieved in the gastric mucous layer or epithelial cell surfaces where H. pylori exists. One way to improve the efficacy is to deliver the antibiotic locally in the stomach using floating and/or mucoadhesive polymers. Sodium Alginate (SA), Ethyl Cellulose (EC), and Eudragit RS100 are examples of polymers commonly used in gastroretentive dosage forms. The main objective of this study was to investigate the possible effect of these polymers on the in-vitro anti-H. pylori activity of a third generation fluoroquinolone antibacterial agent; Lomefloxacin hydrochloride (LFX). The in-vitro activity of free LFX and LFX-polymer blends (SA, EC, or RS100) were carried out against clinical isolates of H. pylori and the Minimal Inhibitory Concentrations (MIC) were determined by agar dilution susceptibility method.

Keywords

Helicobacter pylori (H. pylori), Lomefloxacin hydrochloride (LFX), Sodium Alginate (SA), Ethyl Cellulose (EC), Eudragit RS100, Blend Film