CJ-VOLUME 03 ISSUE 03 MAY 2013


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Volume 3 Issue 3, May 2013

Chemistry Journal

ISSN

2049-954X

Publication Frequency

6 Issues per year

Pages

81-111

Publication History


Original Articles

Sequential Potentiometric Determination of Nitrate and Chloride in Vegetables

R. Pérez-Olmos, X. Gabiola and J.M. Hurtado

Pages 81-85


Kinetics of the Inhibitory Effects of Ethanolic Extract of Vernonia amydgalina on the Corrosion of Aluminium in 1.0 M HCl

K.T. Dauda, V.N.Atasie and A.A. Adetimilehin

Pages 86-89


Synthesis and Characterization of Well-Defined Regular Star Polyisoprenes with 3, 4, 6 and 8 Arms

Kedar R. Ratkanthwar, Nikos Hadjichristidis and Pudukulathan Zubaidha

Pages 90-96

Role of PLGA-Nanoparticles Formulation to Improve Drug Radioprotective Activity in Gamma-Irradiated Mice

Amir Ibrahim Mohamed, Mona I.A. El-Assal, Mohamed A. Kassem, Osama A.A. Ahmed

Pages 97-104


Role of Natural Biodegradable Microspheres to Improve Bioavailability Of Certain Anti-Anaemic Drugs in Rat

Ali Saeed El-badrawy, Mona Ibrahim Abd El-Tawab El-Assal, Mohamed A. Kassem

Pages 105-111


Title

Sequential Potentiometric Determination of Nitrate and Chloride in Vegetables

Abstract

A rapid and simple sequential potentiometric method is described for the determination of nitrate and chloride ions in vegetables, by using home-made ion selective electrodes. The extraction of both ions from the vegetable samples was effected by magnetic stirring of the samples during 30 min in water at room temperature. Direct Potentiometry was used as analytical technique for measurement. The mean coefficient of variation, the average percentage of spike recovery and the detection limit for the nitrate determination in 17 samples of different vegetables were found to be 1.7%, 100.5% and 0.12 g Kg-1 respectively. These values were found to be 2.3%, 100.6% and 0.08 g kg-1 for the chloride ion. The mean nitrate and chloride ion concentrations determined by application of the proposed potentiometric method were found to be 7.18 g kg-1 and 5.07 g kg-1, respectively.  In addition Comparison of variances (F- test) and linear regression analysis of the results obtained were carried out to validate the developed sequential potentiometric method.

Keywords

Potentiometry, Nitrate and Chloride Selective Electrodes, Vegetables, Linear Regression


Title

Kinetics of the Inhibitory Effects of Ethanolic Extract of Vernonia amydgalina on the Corrosion of Aluminium in 1.0 M HCl

Abstract

The inhibition efficiency of ethanolic extract of Vernonia amygdalina (V. amygdalina) extract on aluminium in hydrochloric acid (HCl) solutions has been evaluated by weight loss technique. Values of inhibition efficiency obtained were dependent upon the concentration of inhibitor and temperature. Inhibition increased as inhibitor concentration, half-life, activation energy was increased but decrease with temperature and first-order rate constant at the temperatures studied. Physical adsorption mechanism has been proposed for the inhibition and Langmuir adsorption isotherm was obeyed.

Keywords

Corrosion Inhibition, Aluminium, Weight Loss, Vernonia amygdalina, Hydrochloric Acid


Title

Synthesis and Characterization of Well-Defined Regular Star Polyisoprenes with 3, 4, 6 and 8 Arms

Abstract

Three series of regular well-defined star polyisoprenes (PIs) with 3, 4 and 6 arms (each series: same arm molecular weight) have been synthesized by anionic polymerization high vacuum techniques and chlorosilane chemistry. In addition, three linear PIs with practically the double arm molecular weight of the corresponding series (2-arm star PIs) have been synthesized, as well as one 8-arm star PI. All intermediate (arms) and final (stars) products have been characterized by size exclusion chromatography (SEC), SEC-multi-angle laser light scattering (SEC-MALLS) and nuclear magnetic resonance (NMR) spectroscopy. The Tg of the star PIs was determined by differential scanning calorimetry. These model polymeric materials are essential for polymer physics and polymer physical chemistry in order to establish the structure/property relationships.

Keywords

 High Vacuum Techniques, Star-Branched Polymers, Star Polyisoprene, SEC


Title

Role of PLGA-Nanoparticles Formulation to Improve Drug Radioprotective Activity in Gamma-Irradiated Mice

Abstract

Radioprotective agents are synthetic compounds or natural products that are immediately administrated before irradiation to reduce injuries caused by ionizing radiation. Toxicity, short duration, and the unfavourable routes of administration, have prevented the widespread use of most radioprotective agents in practice. This study aimed to evaluate the use of slowly release- long circulation biodegradable polymer Poly(lactide-co-glycolide) (PLGA) as carrier for certain water-soluble radioprotective agents. Penicillamine and Potassium Iodide (KI) were selected as examples of radioprotectors which can be used to protect against both internal radionuclide (chronic radiation exposure) and external-beam irradiation (acute radiation exposure). Emulsion-solvent evaporation method (ESE) was used to prepare hydrophilic-drug loaded PLGA Nanoparticles (PLGA-NPs) in an efficient and reproducible manner. The radioprotective efficacy of free drug and drug-loaded NPs was assessed by 30 days-survival percentage, relative body weights, and (liver & spleen) total cell count methods.

Keywords

Biodegradable Nanoparticles, Radioprotective drugs, Penicillamine, Potassium iodide, PLGA, Gamma-ray


Title

Role of Natural Biodegradable Microspheres to Improve Bioavailability Of Certain Anti-Anaemic Drugs in Rat

Abstract

Iron deficiency anaemia, the second most common cause of anaemia in the elderly, usually results from chronic gastrointestinal (GI) blood loss. One of the most attractive areas of research in drug delivery today is the design of micro-particulate systems (microspheres) that are able to deliver drugs to the right place, at appropriate times and at the right dosage. The ability of natural biodegradable polymers as (sodium alginate and sodium carboxymethyl cellulose) to swell and regulate the release of encapsulated certain anti-anaemic drugs such as (ferrous sulphate and ferrous fumarate) by controlling crosslinking makes them attractive as materials in the controlled release of drugs. The rat iron repletion test was subsequently adapted as the standard method of analysis for the availability of iron.

Keywords

Iron Deficiency Anaemia, Iron Repletion Test, Microspheres, Sodium Alginate, Sodium Carboxymethyl Cellulose